Lu Meng Lab - Peking University Health Science Center

Research

🧠 Deep Learning & Brain-inspired Intelligence

AI for Science & Multimodal Biological Foundation Models

Focusing on the intersection of deep learning, artificial intelligence, and neuroscience, we build multimodal biological foundation models, promote innovative AI applications in life sciences, medicine, and brain science, and explore brain-inspired mechanisms of intelligent systems.

🧬 Neurobiology

Structure and Dynamics of Neuronal Networks

Studying the structure and dynamic properties of neuronal networks and their impact on information processing and cognitive functions, combining theoretical modeling, experimental data, and AI methods to reveal the operating mechanisms of neural systems.

🔬 Multimodal Imaging Methods

Development and Modeling of Multimodal Imaging Technologies

Developing and applying multimodal imaging technologies, combined with AI analysis, to deeply investigate key phenomena in neurobiology and advance the frontiers of brain science.

Team

Lu Meng

Principal Investigator / Assistant Professor

Focuses on AI for Science and neurobiology, committed to promoting innovative AI applications in life sciences.

Profile Google Scholar

An Jialiang

Master Student

Focuses on the development and application of multimodal biological foundation models.

Qiu Shuowen

PhD Student

Focuses on experiments and data analysis of neurobiological phenomena.

Jiang Yunhan

PhD Student

Researches neuronal network modeling and dynamic analysis.

Selected Publications

Graphene Microelectrode Arrays, 4D Structured Illumination Microscopy, and a Machine Learning Spike Sorting Algorithm Permit the Analysis of Ultrastructural Neuronal Changes During Neuronal Signaling in a Model of Niemann–Pick Disease Type C

Lu, M., Hui, E., Brockhoff, M., Träuble, J., Fernandez‐Villegas, A., Burton, O. J., ... & Kaminski Schierle, G. S.

Advanced Science, 2024.

ERnet: a tool for the semantic segmentation and quantitative analysis of endoplasmic reticulum topology

Lu M, Christensen CN, Weber J, Konno T, Läubli N, Scherer K, Lapkin A, Lio P, Avezov E, Kaminski Schierle GS, Kaminski CF.

Nature Methods, 2023.

The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes

Lu M, van Tartwijk FW, Lin JQ, Nijenhuis W, Parutto P, Fantham M, Christensen CN, Avezov E, Holt CE, Tunnacliffe A, Holcman D, Kapitein L, Kaminski Schierle GS, Kaminski CF.

Science Advances, 2020.

Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multiparametric imaging

Lu M, Williamson N, Mishra A, Michel CH, Kaminski CF, Tunnacliffe A, Kaminski Schierle GS.

J. Biol. Chem., 2019.

A mathematical framework of intelligence and consciousness based on Riemannian Geometry

Lu M.

arXiv, 2024.

Advances in the study of organelle interactions and their role in neurodegenerative diseases enabled by super-resolution microscopy

Lu M, Ward E, van Tartwijk FW, Kaminski CF.

Neurobiology of Disease, 2021.

Synthetic peptides derived from sea cucumber alleviate oxidative stress in neuroblastoma cells and improve survival in Caenorhabditis elegans exposed to neurotoxic paraquat

Lu M, Mishra A, Boschetti C, Kaminski CF, Huang Z, Tunnacliffe A, Kaminski Schierle GS.

Oxidative Medicine and Cellular Longevity, 2021.

Advanced fluorescence imaging of in situ protein aggregation

Lu M, Kaminski CF, Kaminski Schierle GS.

Physical Biology, 2020.

News

June 2024

Lab Recruiting First Graduate Students

Welcome students interested in the intersection of AI and neurobiology to join Lu Meng Lab!

January 2024

Lu Meng Lab Officially Established

Lu Meng Lab was established in January 2024 at Peking University Health Science Center, dedicated to AI for Science, neurobiology, and multimodal imaging research.

Contact

📍

Address

Room 411, North Building, Medical Science and Technology Building, Peking University (Xueyuan Road Campus), Haidian District, Beijing

📧

Email

menglu@pku.edu.cn

Welcome to Lu Meng Lab